For mothers undergoing treatment for thyroid eye disease (TED), the medication Tepezza has been a beacon of hope. This was the only approved FDA drug to treat TED. Hence, it shone into the limelight in no time.
However, as more women embrace this therapeutic option, a troubling side effect has emerged from the shadows: ototoxicity. This condition, characterized by hearing loss and other auditory disturbances, poses a significant threat to maternal health and well-being.
As a mother, the ability to communicate and bond with your child is paramount. The prospect of losing that precious connection due to medication-induced hearing impairment is nothing short of terrifying.
In this blog post, we will explore the complex relationship between Tepezza and ototoxicity, shedding light on the risks and challenges. We will also explore potential solutions for mothers navigating this unexpected journey.
Tepezza and Thyroid Eye Disease
In maternity, your body embarks on a remarkable journey, nurturing a new life while adapting to a multitude of physical and emotional changes. However, pre-existing health conditions can pose unforeseen challenges during this delicate period.
According to the Cleveland Clinic, thyroid eye disease (TED) is an autoimmune disorder affecting the tissues surrounding the eyes. This condition often manifests with bulging eyes, eyelid retraction, and, in
severe cases, vision impairment.
Moreover, it affects women more than men. The disease affects 16 out of every 100,000 individuals assigned female at birth and 2.9 out of every 100,000 individuals assigned male at birth.
Enter Tepezza, a groundbreaking medication offering a glimmer of hope for pregnant and breastfeeding mothers struggling with TED. Unlike traditional treatments that manage symptoms, Tepezza employs a sophisticated biological mechanism.
According to TorHoerman Law, it binds to a specific protein complex known as the insulin-like growth factor-1 receptor (IGF-1R). This receptor is critical in stimulating the growth and activity of orbital fibroblasts. These are the cells responsible for the inflammation and tissue expansion characteristic of TED.
By binding to IGF-1R, Tepezza blocks its signaling pathway, disrupting the communication between these cells and halting their excessive activity. This focused strategy is designed to stop the advancement of the disease and undo its impact.
But the question arises: Is Tepezza a safe and effective option for mothers? There have been growing concerns about the drug’s serious hearing-related side effects. With mothers strongly relying on their infant’s hearing cues to nurture them, is Tepezza worth the risk?
Tepezza and Ototoxicity
Ototoxicity, a potential side effect of Tepezza, is a serious concern for mothers undergoing treatment for thyroid eye disease. This issue arises when the medicine causes harm to the delicate structures of the inner ear, including the hair cells and auditory nerve.
The specific mechanisms of Tepezza-induced ototoxicity are not fully understood. However, it is thought to be related to the drug’s ability to disrupt normal cellular processes in the ear. According to the MSD Manual, higher doses of medications and pre-existing kidney issues can exacerbate the threat.
Moreover, infusion rate, particularly for intravenous medications, may also play a role. Genetic susceptibility adds another layer of concern.
Mothers taking Tepezza should be aware of the risk factors that may increase their likelihood of developing ototoxicity. Symptoms to watch for include tinnitus (ringing in the ears), hearing loss, and vertigo. These conditions can make it difficult for mothers to care for their children and engage in daily activities.
If left untreated, ototoxicity can lead to permanent hearing damage, impacting your ability to communicate with your child and hindering the critical bonding process.
Maternity is a symphony of sights and sounds. Day in and day out, you would be waiting for your infant’s first gurgles and the early attempts at speech. These are precious moments that rely heavily on your ability to hear clearly.
Not being able to hear can have long-lasting effects on the child’s development and the mother-child relationship. Therefore, you must be informed about the risks and closely monitor your hearing health during Tepezza treatment.
Can You Sue Tepezza Manufacturers?
The drug was marketed as safe and approved by the FDA in 2020. Moreover, even the initial trials promised great results. In such a scenario, it is natural for any TED patient to look at Tepezza as a miracle treatment.
The drug manufacturer, Horizon Therapeutics, conveniently hid the facts about the medication’s hearing side effects for profit. This exercise of monopoly and taking helpless patients for a ride has triggered public ire.
Many affected are suing the company for neglecting consumer safety and falsely marketing its product. So, the answer is yes—even you can file a Tepezza hearing loss lawsuit if you suffer severe hearing impairment because of the drug. Make sure to team up with experienced attorneys to navigate the murky legal landscape associated with medicines.
Your lawyer will help you document your medical journey and keep all bills intact. These will serve as concrete proof of your suffering. Moreover, they will help you manage legal deadlines like the statute of limitations so you do not miss the chance of suing the perpetrator.
Balancing Your Baby’s Needs and Your Hearing Health
While Tepezza offers a beacon of hope in managing thyroid eye disease, the possibility of hearing loss raises a critical question. How can you ensure optimal care for both your vision and hearing during this crucial time?
The good news is that there are alternatives to Tepezza for managing TED in pregnant and breastfeeding mothers. These alternative treatment strategies can be broadly categorized into three groups: corticosteroids, immunosuppressants, and surgical interventions. Each approach has its specific mechanisms of action and risk profile.
Corticosteroids work by reducing inflammation in the eye socket, potentially alleviating symptoms like bulging eyes and eyelid retraction. However, long-term use can come with side effects like weight gain and high blood pressure.
Immunosuppressants, as the name suggests, suppress the overactive immune response that underlies TED. Common immunosuppressants for TED include steroid-sparing agents like mycophenolate mofetil and methotrexate. These drugs reduce inflammation and prevent the immune system from attacking the tissues around the eyes.
These medications can be particularly effective in severe cases but carry an increased risk of infections.
Finally, surgical interventions may be considered for sight-threatening complications of TED. Orbital decompression surgery removes bone and fat from the orbit to create more space for the swollen tissues. This reduces pressure on the optic nerve and improves eye position.
According to Nature, eyelid repositioning surgery, such as levator recession, can help correct eyelid malposition and restore proper eyelid function.
Practical Tips for Moms on Tepezza
Hearing loss after Tepezza treatment can be a blow, but there are steps you can take to stay connected with your baby. Here’s a realistic action plan:
Schedule an Audiologist Appointment
An audiologist can assess your hearing loss and recommend the best course of action. Hearing aids might be a great option, but they aren’t a one-size-fits-all solution. Discuss different models and features to find the most comfortable and effective device for you.
Talk to Your Partner and Family
Open communication is crucial. Explain your hearing loss and how it affects you. Simple things like facing you while talking and avoiding background noise can make a big difference.
Baby Monitors with Alerts
Invest in a reliable baby monitor with visual alerts, like light or vibration, alongside any sound it might have. This ensures you don’t miss anything, even if the sound isn’t always clear. As an example, the VTech DM221 provides a receiver that can easily be attached to your belt. It vibrates to notify you when your baby starts crying. Boasting an impressive 1,000-foot range and an affordable price tag of under $50, this option can be a practical choice for you.
Explore Assistive Technology
Many apps can help bridge the communication gap. Consider captioning apps for watching TV together or amplified phone options for clearer conversations.
Seek Support Groups
Look for online communities or local groups specifically for mothers with hearing loss. Sharing experiences, learning from others, and finding a network of understanding women can be a huge source of strength.
Remember, this is an adjustment, not a limitation. With a proactive approach and the right support system, you can continue to build a strong and loving bond with your baby. Don’t hesitate to ask questions, explore options, and find what works best for you and your family.
FAQs
1. Should I avoid Tepezza altogether if I’m pregnant or breastfeeding?
Tepezza can be a valuable treatment option for some pregnant or breastfeeding mothers with TED. However, the potential for ototoxicity is a serious concern. Discuss the risks and benefits with your doctor to determine the best course of action for your situation.
2. Are there any alternative treatments for TED during maternity?
Yes, there are alternative treatments for TED during maternity, including corticosteroids, immunosuppressants, and surgical interventions. Each approach has its benefits and risks, and your doctor can help you choose the most suitable option.
3. What if I experience hearing loss while taking Tepezza?
If you experience any hearing loss while taking Tepezza, it’s crucial to inform your doctor immediately. They can monitor your hearing and recommend appropriate management strategies, such as audiologist consultations or exploring hearing aids.
In final words, motherhood is a delicate dance, a constant negotiation between your well-being and your baby’s thriving health. The discovery of a potential link between Tepezza and hearing loss adds another layer of complexity to this beautiful journey.
While Tepezza offers a beacon of hope for managing thyroid eye disease, the possibility of hearing loss necessitates a nuanced approach. Remember, you are not alone.
By embracing a proactive approach to monitoring your hearing health, you can navigate this challenge with confidence. The music of motherhood may have a slightly different melody, but the love that binds you and your child will remain the same.
